PF-03654746

Ligand id: 9058

Name: PF-03654746

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 32.34
Molecular weight 322.19
XLogP 3.1
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide
Synonyms
compound 6 [PMID: 21928839] | PF 03654746 | PF03654746
Database Links
BindingDB Ligand 50401003
CAS Registry No. 935840-31-6 (source: PubChem)
ChEMBL Ligand CHEMBL2151197
PubChem CID 16119086
Search Google for chemical match using the InChIKey SXMBKHYDZOCBMT-UHFFFAOYSA-N
Search Google for chemicals with the same backbone SXMBKHYDZOCBMT
Search UniChem for chemical match using the InChIKey SXMBKHYDZOCBMT-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone SXMBKHYDZOCBMT
Wikipedia PF-03654746
Comments
PF-03654746 is a potent and selective, investigational histamine H3 receptor antagonist [2], with potetial as an antiinflammatory agent [1] and with potential to treat human cognitive disorders.