PL-3994

Ligand id: 9067

Name: PL-3994

Classification
Compound class Peptide or derivative
Comments
PL-3994 is a natriuretic peptide receptor-A (NPR-A) agonist, with potential as a bronchodilating therapeutic. It is a cyclo-peptide with sequence Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH2 [1]. This peptide benefits from being resistant to enzymatic degradation by neutral endopeptidase (a.k.a. NEP or neprilysin), the metabolic enzyme of endogenous natriuretic peptides.
Database Links
GtoPdb PubChem SID 315661152