Synonyms: (S)-JQ-35 | (S)-JQ35 | RG6146 | Ro-6870810 | RO-6870810 | RO6870810 | TEN010
Compound class:
Synthetic organic
Comment: TEN-010 (RO6870810) is a BET inhibitor [3]. Structurally it is an analogue of (+)-JQ1, with optimised chemical and biological properties. Development of TEN-010 was progressed by Roche, who acquired the originating biotech firm Tensha Therapeutics. Tensha claimed several bromodomain inhibitors in patent WO2016069578 [1].
BET inhibitors bind to the bromodomains of the bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4, and BRDT. This mechanism acts to prevent protein-protein interaction between BET proteins and acetylated histones and transcription factors. The action disrupts chromatin remodeling and inhibits expression of some growth-promoting genes which slows proliferation in susceptible tumours. |
|
Classification | |
Compound class | Synthetic organic |
Synonyms |
(S)-JQ-35 | (S)-JQ35 | RG6146 | Ro-6870810 | RO-6870810 | RO6870810 | TEN010 |
Database Links | |
BindingDB Ligand | 483491 |
ChEMBL Ligand | CHEMBL4297423 |
DrugBank Ligand | DB15151 |
GtoPdb PubChem SID | 315661203 |
PubChem CID | 54670351 |
Search Google for chemical match using the InChIKey | PKQXLRYFPSZKDU-QFIPXVFZSA-N |
Search Google for chemicals with the same backbone | PKQXLRYFPSZKDU |
UniChem Compound Search for chemical match using the InChIKey | PKQXLRYFPSZKDU-QFIPXVFZSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | PKQXLRYFPSZKDU-QFIPXVFZSA-N |