PEN

Ligand id: 9139

Name: PEN

Species: Mouse

Classification
Compound class Endogenous peptide in human, mouse or rat
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor Mouse ProSAAS basic protein IA-4, MGC:19107, Pan3, proSAAS
Comments
Neuroendocrine peptide PEN is one of the peptide fragments cleaved from the pro-peptide ProSAAS (encoded by the Pcsk1n gene). Mouse PEN comprises amino acids 219-240 of the pro-protein. PEN activity in the brain is implicated in the regulation of feeding. PEN has been identified as an endogenous ligand for GPR83 [1]. It is suggested that the PEN-GPR83 and BigLEN-GPR171 ligand-receptor systems may be functionally coupled as a mechanism to regulate feeding.