GSK2245035

Ligand id: 9254

Name: GSK2245035

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 96.61
Molecular weight 390.27
XLogP 2.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
6-amino-2-[(2S)-pentan-2-yloxy]-9-[5-(piperidin-1-yl)pentyl]-8,9-dihydro-7H-purin-8-one
Synonyms
compound 32 [PMID: 26861551]
Database Links
PubChem CID 44623937
Search Google for chemical match using the InChIKey LFMPVTVPXHNXOT-HNNXBMFYSA-N
Search Google for chemicals with the same backbone LFMPVTVPXHNXOT
Search UniChem for chemical match using the InChIKey LFMPVTVPXHNXOT-HNNXBMFYSA-N
Search UniChem for chemicals with the same backbone LFMPVTVPXHNXOT
Comments
GSK2245035 is reported as a selective Toll-like receptor 7 (TLR7) agonist, with potential clinical action as an intranasally administered anti-asthmatic [2]. It is Example 22 claimed in patent WO2010018133 [3].

The TLR7- IFNα pathway is a novel pathway being investigated for pharmacological intervention in allergic asthma.