ACT-462206

Ligand id: 9303

Name: ACT-462206

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 84.09
Molecular weight 388.15
XLogP 4.04
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(2S)-N-(3,5-dimethylphenyl)-1-(4-methoxyphenyl)sulfonylpyrrolidine-2-carboxamide
Synonyms
compound 24 [PMID: 25147058]
Database Links
Search Google for chemical match using the InChIKey NHPQGZOBHSVTAQ-IBGZPJMESA-N
Search Google for chemicals with the same backbone NHPQGZOBHSVTAQ
Comments
ACT-462206 is an orally active, potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist [1]. ACT-462206 is being developed by Actelion Pharmaceuticals for clinical potential as a sleep disorder therapeutic.