JNJ-42847922

Ligand id: 9308

Name: JNJ-42847922

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 80.04
Molecular weight 407.19
XLogP 2.58
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
[2-(4,6-dimethylpyrimidin-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone
Synonyms
JNJ-922 | MIN-202
Database Links
BindingDB Ligand 118454
PubChem CID 67116280
Search Google for chemical match using the InChIKey SQOCEMCKYDVLMM-UHFFFAOYSA-N
Search Google for chemicals with the same backbone SQOCEMCKYDVLMM
Search UniChem for chemical match using the InChIKey SQOCEMCKYDVLMM-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone SQOCEMCKYDVLMM
Comments
JNJ-42847922 is an investigational, selective OX2 receptor antagonist (2-SORA) [1]. It is one of the compounds claimed in patent WO2011050198, where it is Example 107 [2]. This compound is being developed jointly by Minerva Neurosciences and Janssen Pharmaceuticals for the treatment of major depression disorder and insomnia.