SAR405

Ligand id: 9353

Name: SAR405

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 48.91
Molecular weight 443.13
XLogP 2.59
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(8S)-9-[(5-chloropyridin-3-yl)methyl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(trifluoromethyl)-7,8-dihydro-6H-pyrimido[1,2-a]pyrimidin-4-one
Synonyms
SAR-405
Database Links
CAS Registry No. 1523406-39-4 (source: PubChem)
ChEMBL Ligand CHEMBL3622372
PubChem CID 72709209
Search Google for chemical match using the InChIKey SPDQRCUBFSRAFI-DOMZBBRYSA-N
Search Google for chemicals with the same backbone SPDQRCUBFSRAFI
Search UniChem for chemical match using the InChIKey SPDQRCUBFSRAFI-DOMZBBRYSA-N
Search UniChem for chemicals with the same backbone SPDQRCUBFSRAFI
Comments
SAR405 is a small molecule inhibitor selective for the lipid kinase, vacuolar protein sorting 34 (Vps34; PIK3C3), a kinase with roles in autophagy and vesicle trafficking [1].