VLX1570

Ligand id: 9413

Name: VLX1570

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 123.66
Molecular weight 469.11
XLogP 4.86
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-acryloyl-3,5-bis((Z)-4-fluoro-3-nitrobenzylidene)azepan-4-one
Synonyms
VLX-1570
Database Links
PubChem CID 118989091
Search Google for chemical match using the InChIKey SCKXBVLYWLLALY-CQRYCMKKSA-N
Search Google for chemicals with the same backbone SCKXBVLYWLLALY
Search UniChem for chemical match using the InChIKey SCKXBVLYWLLALY-CQRYCMKKSA-N
Search UniChem for chemicals with the same backbone SCKXBVLYWLLALY
Comments
VLX1570 is a competitive, reversible inhibitor of 19S proteasome-specific deubiquitylating enzymes, including ubiquitin-specific protease-14 (USP14) and ubiquitin-C-terminal hydrolase-5 (UCHL5) [1-2]; being investigated for antineoplastic/antiproliferative efficacy.