VLX1570

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Ligands
VLX1570

Ligand id: 9413

Name: VLX1570

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	3
Hydrogen bond donors	0
Rotatable bonds	6
Topological polar surface area	123.66
Molecular weight	469.11
XLogP	4.86
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

Classification
Compound class	Synthetic organic

IUPAC Name
1-acryloyl-3,5-bis((Z)-4-fluoro-3-nitrobenzylidene)azepan-4-one

IUPAC Name

1-acryloyl-3,5-bis((Z)-4-fluoro-3-nitrobenzylidene)azepan-4-one

Synonyms
VLX-1570

Synonyms

VLX-1570

Database Links
GtoPdb PubChem SID	328083515
PubChem CID	118989091
Search Google for chemical match using the InChIKey	SCKXBVLYWLLALY-CQRYCMKKSA-N
Search Google for chemicals with the same backbone	SCKXBVLYWLLALY
Search UniChem for chemical match using the InChIKey	SCKXBVLYWLLALY-CQRYCMKKSA-N
Search UniChem for chemicals with the same backbone	SCKXBVLYWLLALY

Comments
VLX1570 is a competitive, reversible inhibitor of 19S proteasome-specific deubiquitylating enzymes, including ubiquitin-specific protease-14 (USP14) and ubiquitin-C-terminal hydrolase-5 (UCHL5) [1-2]; being investigated for antineoplastic/antiproliferative efficacy.

Comments

VLX1570 is a competitive, reversible inhibitor of 19S proteasome-specific deubiquitylating enzymes, including ubiquitin-specific protease-14 (USP14) and ubiquitin-C-terminal hydrolase-5 (UCHL5) [1-2]; being investigated for antineoplastic/antiproliferative efficacy.