TP-064

Ligand id: 9528

Name: TP-064

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 57.7
Molecular weight 458.27
XLogP 5.22
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-methyl-N-[[2-[1-[2-(methylamino)ethyl]piperidin-4-yl]pyridin-4-yl]methyl]-3-phenoxybenzamide
Synonyms
TP 064
Database Links
PubChem CID 122707126
RCSB PDB Ligand 7VM
Search Google for chemical match using the InChIKey VUIITYLFSAXKIQ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone VUIITYLFSAXKIQ
Search UniChem for chemical match using the InChIKey VUIITYLFSAXKIQ-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone VUIITYLFSAXKIQ
Comments
TP-064 is a potent, selective and cell active chemical probe for PRMT4 (officially known as coactivator associated arginine methyltransferase 1; CARM1) [1]. It is one of the chemical tools in the Structural Genomics Consortium's Epigenetic Probes Collection and was developed in collaboration with Takeda.