foliglurax

Ligand id: 9622

Name: foliglurax

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 95.42
Molecular weight 421.15
XLogP 3.76
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-{6-[3-(morpholin-4-yl)propyl]-2-{thieno[3,2-c]pyridin-6-yl}-4H-chromen-4-ylidene}hydroxylamine
International Nonproprietary Names
INN number INN
10686 foliglurax
Synonyms
DT1687 | PXT-002331 | PXT002331
Comments
Prexton Therapeutics is developing foliglurax (PXT002331; a compound originally identified by Merck), as an orally active metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulator (PAM), for symptomatic relief in Parkinson's disease, as an alternative to dopamine replacement therapies. Listings on ClinicalTrials.gov associate the research code PXT002331 to the INN foliglurax. To generate the structure we used the IUPAC name submitted to the WHO for the INN foliglurax to generate SMILES using Chemicalize.
Database Links
GtoPdb PubChem SID 340590252
Search Google for chemical match using the InChIKey ZTEDNASHAWNBKQ-UHFFFAOYSA-N
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Search PubMed clinical trials foliglurax
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Search UniChem for chemical match using the InChIKey ZTEDNASHAWNBKQ-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone ZTEDNASHAWNBKQ