RIPA-56

Ligand id: 9643

Name: RIPA-56

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 40.54
Molecular weight 221.14
XLogP 3.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-benzyl-N-hydroxy-2,2-dimethylbutanamide
Synonyms
compound 56 [PMID: 27992216] | compound 92 [WO2016101885]
Database Links
PubChem CID 121439991
Search Google for chemical match using the InChIKey AVYVHIKSFXVDBG-UHFFFAOYSA-N
Search Google for chemicals with the same backbone AVYVHIKSFXVDBG
Search UniChem for chemical match using the InChIKey AVYVHIKSFXVDBG-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone AVYVHIKSFXVDBG
Comments
RIPA-56 is a highly potent, selective, and metabolically stable type III (allosteric) inhibitor of receptor-interacting protein kinase 1 (RIPK1) [2]. It is claimed as compound 92 in patent WO2016101885 [3]. RIPA-56 is a drug candidate for the treatment of systemic inflammatory response syndrome (SIRS).