VU6010608

Ligand id: 9703

Name: VU6010608

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 86.98
Molecular weight 408.1
XLogP 3.01
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
3,4-dimethoxy-N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl]benzamide
Synonyms
compound 11a [Reed et al., 2017)
Comments
VU6010608 is a selective, negative allosteric modulator (NAM) of metabotropic glutamate receptor mGlu7 [1], and represents a novel chemotype. VU6010608 is CNS penetrant and effective in electrophysiology studies making it an ideal tool compound suitable for investigating the physiology and therapeutic potential of mGlu7, however, its in vivo utility is limited by total and free levels achieved in the brain.
Database Links
GtoPdb PubChem SID 348353662
PubChem CID 131801162
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Search UniChem for chemical match using the InChIKey YCDOKDADFOBKIL-UHFFFAOYSA-N
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