semaglutide

Ligand id: 9724

Name: semaglutide

Structure and Physico-chemical Properties

2D Structure
Classification
Compound class Peptide or derivative
Approved drug? Yes (FDA (2017))
International Nonproprietary Names
INN number INN
9113 semaglutide
Synonyms
NN-9535 | NN9535 | Ozempic®
Comments
Semaglutide is a glucagon like peptide 1 (GLP-1) receptor peptidomimetic agonist [2]. Structurally it is a modified analogue of glucagon-like peptide 1-(7-37) with amino acids at positions 8 and 34 replaced by α-aminobutyric acid and arginine respectively, and Lys26 is acylated with stearic diacid. Semaglutide has slightly lower GLP-1 receptor affinity than liraglutide, but this is compensated by an increased serum albumin affinity, which ensures improved resistance to metabolic degradation.
Database Links
CAS Registry No. 910463-68-2 (source: WHO INN record)
GtoPdb PubChem SID 354702201
PubChem CID 56843331
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