teneligliptin

Ligand id: 9906

Name: teneligliptin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 81.94
Molecular weight 426.22
XLogP 2.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (Japan (2012), S Korea (2014))
IUPAC Name
[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone
International Nonproprietary Names
INN number INN
8994 teneligliptin
Synonyms
compound 8g [PMID: 22959556] | MP-513 | MP513 | Teneli
Comments
Teneligliptin is a long-acting, orally bioavailable dipeptidyl peptidase 4 (DPP-4) inhibitor [3]. It was developed for clinical potential in type 2 diabetes management, to improve glycemic control. In addition to their anti-diabetic activity, DPP4 inhibitors may have renal and cardiovascular protective effects.
Database Links
BindingDB Ligand 50391565
CAS Registry No. 760937-92-6 (source: WHO INN record)
ChEMBL Ligand CHEMBL2147777
DrugBank Ligand DB11950
GtoPdb PubChem SID 363894200
PubChem CID 11949652
RCSB PDB Ligand M51
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SynPHARM 85060 (in complex with dipeptidyl peptidase 4)