tucatinib

Ligand id: 9922

Name: tucatinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 110.85
Molecular weight 480.2
XLogP 3.75
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
International Nonproprietary Names
INN number INN
9997 tucatinib
Synonyms
ARRY-380 | Example 11 [WO2007059257A2] | ONT-380
Comments
Tucatinib is a ERBB2 (HER2) receptor tyrosine kinase inhibitor that was developed as a novel antineoplastic agent. The chemical structure is claimed as Example 11 in Array Biopharma patent WO2007059257A2 [2], and was exemplified as ARRY-380 in the later patent WO2013056183A1 [1].
The INN tucatinib replaced the earlier INN irbinitinib associated with this chemical entity.
Database Links
CAS Registry No. 937263-43-9 (source: WHO INN record)
GtoPdb PubChem SID 363894216
PubChem CID 51039094
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