Ligand id: 9955

Name: artemether

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 46.15
Molecular weight 298.18
XLogP 3.33
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Compound class Natural product or derivative
Ligand families/groups Antimalarial ligands
Approved drug? Yes (FDA (2009) in combination with lumefantrine)
International Nonproprietary Names
INN number INN
6458 artemether
β-artemether | beta-artemether
Artemether is a semisynthetic derivative of artemisinin, a natural product isolated from the quinghaosu or sweet wormwood plant (Artemisia annua). Synthesis yields two crystalline anomers, α- and β-artemether, the latter predominates and is marginally more active [2].
Artemether is a prodrug that is converted to the active metabolite artenimol (dihydroartemisinin). It has potent antimalarial activity against the asexual blood stage of P. falciparum (including chloroquine-resistant strains) and is characterised by an extremely rapid parasitemia clearance.

Artemether is listed in the WHO 20th Essential Medicines List (2017) as an antimalarial for use in the management of severe malaria. It is also listed as a curative treatment for uncomplicated P. falciparum malaria in combination with lumefantrine. This is one of the artemisinin-based combination therapies (ACTs) recommended in the WHO Guidelines for the treatment of malaria [4].

Potential Target/Mechanism Of Action: As the precise mechanism of action of artemether is not yet known, we do not have a molecular target for this compound.
Database Links
CAS Registry No. 71963-77-4 (source: Scifinder)
ChEBI CHEBI:195280
ChEMBL Ligand CHEMBL566534
DrugBank Ligand DB06697
GtoPdb PubChem SID 374883842
PubChem CID 68911
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Wikipedia Artemether