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Target not currently curated in GtoImmuPdb
Target id: 2953
Nomenclature: Zika virus genome polyprotein
Systematic Nomenclature: Zika virus (strain Mr 766) (ZIKV) polyprotein
Family: Other viral proteins
Database Links  |
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| UniProtKB | A0A140DLX4 (ZIKV) |
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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| General Comments |
| This polyprotein precursor is proteolytically processed inside the host cell to spawn a number of separate activities (see GO terms in UniProt entry), including enzymes that are important for viral replication. Several of these are being pursued as novel anti-viral drug targets. |
1. Shiryaev SA, Farhy C, Pinto A, Huang CT, Simonetti N, Ngono AE, Dewing A, Shresta S, Pinkerton AB, Cieplak P et al.. (2017) Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists. Antiviral Res, 143: 218-229. [PMID:28461069]
Other viral proteins: Zika virus genome polyprotein. Last modified on 31/03/2020. Accessed on 16/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2953.
