Fatty acid transport protein 1

Target id: 1108

Nomenclature: Fatty acid transport protein 1

Abbreviated Name: FATP1

Systematic Nomenclature: SLC27A1

Family: SLC27 family of fatty acid transporters

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Fatty acid transport protein 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - SLC27A1 solute carrier family 27 member 1
Mouse - - Slc27a1 solute carrier family 27 (fatty acid transporter), member 1
Rat - - Slc27a1 solute carrier family 27 member 1
Previous and Unofficial Names
Long-chain fatty acid transport protein 1 | solute carrier family 27 member 1 | ACSVL5 | FATP | solute carrier family 27 (fatty acid transporter), member 1 | solute carrier family 27 (fatty acid transporter)
Database Links
Specialist databases
Bioparadigms SLC Tables SLC27A1 (Hs)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
Endogenous substrates (Human)
arachidonic acid > palmitic acid > oleic acid > butyric acid  [3]
Endogenous substrates (Human)
palmitic acid > oleic acid > γ-linolenic acid > octanoic acid  [1]

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 5k [PMID: 23528296] Hs Inhibition 7.3 pIC50 2
pIC50 7.3 (IC50 4.6x10-8 M) [2]


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1. Gimeno RE, Ortegon AM, Patel S, Punreddy S, Ge P, Sun Y, Lodish HF, Stahl A. (2003) Characterization of a heart-specific fatty acid transport protein. J. Biol. Chem., 278 (18): 16039-44. [PMID:12556534]

2. Matsufuji T, Ikeda M, Naito A, Hirouchi M, Kanda S, Izumi M, Harada J, Shinozuka T. (2013) Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorg. Med. Chem. Lett., 23 (9): 2560-5. [PMID:23528296]

3. Schaffer JE, Lodish HF. (1994) Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell, 79 (3): 427-36. [PMID:7954810]

How to cite this page

SLC27 family of fatty acid transporters: Fatty acid transport protein 1. Last modified on 18/09/2015. Accessed on 22/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1108.