<i>GPR62</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

GPR62

Target id: 111

Nomenclature: GPR62

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for GPR62 in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 368 3p21.1-p21.9 GPR62 G protein-coupled receptor 62 1
Mouse 7 358 9 F1 Gpr62 G protein-coupled receptor 62
Rat 7 358 8q32 Gpr62 G protein-coupled receptor 62
Previous and Unofficial Names
GPCR8
Database Links
Specialist databases
GPCRDB gpr62_human (Hs), gpr62_mouse (Mm), d4a2b1_rat (Rn)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Tissue Distribution
Brain regions (basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen)
Species:  Human
Technique:  Northern blot
References:  1
Tissue Distribution Comments
Transcripts of GPR62 were not detected in the liver when examined by Northern blot analysis [1].
Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  V313L
Global MAF (%):  11
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 36|3|8|2
Minor allele count:  C=0.113/247
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S365R
Global MAF (%):  1
Subpopulation MAF (%):  AFR: 5
Minor allele count:  G=0.011/24
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, Frequency
General Comments
GPR62 has higher expression in the brain, indicating its cognate ligand may be a neurotransmitter [1].

References

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1. Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF. (2001) Identification of four novel human G protein-coupled receptors expressed in the brain. Brain Res. Mol. Brain Res., 86 (1-2): 13-22. [PMID:11165367]

Contributors

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How to cite this page

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: GPR62. Last modified on 16/06/2015. Accessed on 19/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=111.