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Dimethylarginine dimethylaminohydrolases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Dimethylarginine dimethylaminohydrolases (DDAH, EC 3.5.3.18) are cytoplasmic enzymes which hydrolyse NG,NG-dimethyl-L-arginine to form dimethylamine and L-citrulline.

Enzymes

1247
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DDAH1 (NG,NG-Dimethylarginine dimethylaminohydrolase 1) C Show summary »

Target Id 1247
Nomenclature NG,NG-Dimethylarginine dimethylaminohydrolase 1
Common abbreviation DDAH1
Previous and unofficial names DDAHI | dimethylargininase-1 | DDAH
Genes DDAH1 (Hs), Ddah1 (Mm), Ddah1 (Rn)
Ensembl ID ENSG00000153904 (Hs), ENSMUSG00000028194 (Mm), ENSRNOG00000014613 (Rn)
UniProtKB AC O94760 (Hs), Q9CWS0 (Mm), O08557 (Rn)
EC number
3.5.3.18
Cofactors
Zn2+
Inhibitors
compound 2e [PMID: 19013076] pKi 5.7 [1]

DDAH2 (NG,NG-Dimethylarginine dimethylaminohydrolase 2) C Show summary »

References

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How to cite this family page

Database page citation:

Dimethylarginine dimethylaminohydrolases. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=252.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.