<i>GPR149</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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GPR149

Target not currently curated in GtoImmuPdb

Target id: 135

Nomenclature: GPR149

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 731 3q25.2 GPR149 G protein-coupled receptor 149
Mouse 7 732 3 E1 Gpr149 G protein-coupled receptor 149
Rat 7 730 2q31 Gpr149 G protein-coupled receptor 149
Previous and Unofficial Names
IEDA | G-protein coupled receptor PGR10 | induced early in differentiating astrocytes gene protein
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Tissue Distribution
Ovary, brain, digestive tract
Species:  Mouse
Technique:  RT-PCR
References:  1
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Consequences of Altering Gene Expression
Increased fertility and enhanced ovulation, with increased levels of FSH receptor and cyclin D2 mRNA levels, in receptor knockout mice
Species:  None
Tissue:  Oocytes, granulosa cells
Technique:  Gene knockout
References:  1
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
MGI:2443628  MP:0001927 abnormal estrous cycle PMID: 19887567 
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
MGI:2443628  MP:0002161 abnormal fertility/fecundity PMID: 19887567 
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
MGI:2443628  MP:0005410 abnormal fertilization PMID: 19887567 
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
MGI:2443628  MP:0001130 abnormal ovarian folliculogenesis PMID: 19887567 
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
MGI:2443628  MP:0001928 abnormal ovulation PMID: 19887567 
Gpr149+|Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149+
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
MGI:2443628  MP:0001928 abnormal ovulation PMID: 19887567 
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
MGI:2443628  MP:0001934 increased litter size PMID: 19887567 
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
MGI:2443628  MP:0008870 increased mature ovarian follicle number PMID: 19887567 
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
MGI:2443628  MP:0009017 prolonged estrus PMID: 19887567 

References

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1. Edson MA, Lin YN, Matzuk MM. (2010) Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice. Endocrinology, 151 (1): 358-68. [PMID:19887567]

Contributors

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How to cite this page

Stephen P.H. Alexander, Jim Battey, Helen E. Benson, Richard V. Benya, Tom I. Bonner, Anthony P. Davenport, Anthony Harmar, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Wen Chiy Liew, Amy E. Monaghan, Chido Mpamhanga, Richard Neubig, Adam J. Pawson, Jean-Philippe Pin, Joanna L. Sharman, Michael Spedding, Eliot Spindel, Laura Storjohann, Kalyan Tirupula.
Class A Orphans: GPR149. Last modified on 31/07/2015. Accessed on 26/03/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=135.