<i>GPR152</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 138

Nomenclature: GPR152

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 470 11q13.1 GPR152 G protein-coupled receptor 152
Mouse 7 511 19 A Gpr152 G protein-coupled receptor 152
Rat 7 394 1q42 Gpr152 G protein-coupled receptor 152
Previous and Unofficial Names
PGR1 | PGR5 | G-protein coupled receptor PGR5
Database Links
Specialist databases
GPCRDB gp152_human (Hs), gp152_mouse (Mm)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  L317V
Global MAF (%):  9
Subpopulation MAF (%):  AFR|AMR: 39|2
Minor allele count:  C=0.093/204
SNP accession: 
Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  G61R
Global MAF (%):  5
Subpopulation MAF (%):  AMR|ASN: 1|19
Minor allele count:  T=0.054/118
SNP accession: 
Validation:  1000 Genomes, Frequency
General Comments
GPR152 is found to be most closely related to the gamma-group of Rhodopsin family [1].


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1. Gloriam DE, Schiöth HB, Fredriksson R. (2005) Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Biochim. Biophys. Acta, 1722 (3): 235-46. [PMID:15777626]


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How to cite this page

Stephen P.H. Alexander, Jim Battey, Helen E. Benson, Richard V. Benya, Tom I. Bonner, Anthony P. Davenport, Satoru Eguchi, Anthony Harmar, Nick Holliday, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Wen Chiy Liew, Amy E. Monaghan, Chido Mpamhanga, Richard Neubig, Adam J. Pawson, Jean-Philippe Pin, Joanna L. Sharman, Michael Spedding, Eliot Spindel, Leigh Stoddart, Laura Storjohann, Walter (Wally) Thomas, Kalyan Tirupula, Patrick Vanderheyden.
Class A Orphans: GPR152. Last modified on 16/06/2015. Accessed on 19/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=138.