15-LOX-2 | Lipoxygenases | IUPHAR/BPS Guide to PHARMACOLOGY

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Target id: 1389

Nomenclature: 15-LOX-2

Family: Lipoxygenases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for 15-LOX-2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ALOX15B arachidonate 15-lipoxygenase, type B
Mouse - - Alox8 arachidonate 8-lipoxygenase
Rat - - Alox15b arachidonate 15-lipoxygenase, type B
Previous and Unofficial Names
15-lipoxygenase 2 | 15-LOX-B | arachidonate 15-lipoxygenase type II | 8S-lipoxygenase | 8S-LOX | arachidonate 15-lipoxygenase, type B | arachidonate 15-lipoxygenase
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction
EC Number: Arachidonic acid + O2 = 15S-HPETE

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 21n [PMID: 17656086] Hs Inhibition 7.3 pIC50 1
pIC50 7.3 (IC50 5.1x10-8 M) [1]


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1. Weinstein DS, Liu W, Ngu K, Langevine C, Combs DW, Zhuang S, Chen C, Madsen CS, Harper TW, Robl JA. (2007) Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment. Bioorg. Med. Chem. Lett., 17 (18): 5115-20. [PMID:17656086]

How to cite this page

Lipoxygenases: 15-LOX-2. Last modified on 10/09/2015. Accessed on 20/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1389.