15-LOX-2 | Lipoxygenases | IUPHAR/BPS Guide to PHARMACOLOGY

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15-LOX-2

Target not currently curated in GtoImmuPdb

Target id: 1389

Nomenclature: 15-LOX-2

Family: Lipoxygenases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ALOX15B arachidonate 15-lipoxygenase type B
Mouse - - Alox8 arachidonate 8-lipoxygenase
Rat - - Alox15b arachidonate 15-lipoxygenase
Previous and Unofficial Names
15-lipoxygenase 2 | 15-LOX-B | arachidonate 15-lipoxygenase type II | 8S-lipoxygenase | 8S-LOX | arachidonate 15-lipoxygenase, type B | arachidonate 15-lipoxygenase
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.13.11.33 Arachidonic acid + O2 = 15S-HPETE

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
MLS000536924 Hs Inhibition 5.6 pKi 1
pKi 5.6 (Ki 2.5x10-6 M) [1]
compound 21n [PMID: 17656086] Hs Inhibition 7.3 pIC50 2
pIC50 7.3 (IC50 5.1x10-8 M) [2]

References

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1. Jameson 2nd JB, Kantz A, Schultz L, Kalyanaraman C, Jacobson MP, Maloney DJ, Jadhav A, Simeonov A, Holman TR. (2014) A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2. PLoS ONE, 9 (8): e104094. [PMID:25111178]

2. Weinstein DS, Liu W, Ngu K, Langevine C, Combs DW, Zhuang S, Chen C, Madsen CS, Harper TW, Robl JA. (2007) Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: highly potent against human enzyme within a cellular environment. Bioorg. Med. Chem. Lett., 17 (18): 5115-20. [PMID:17656086]

Contributors

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How to cite this page

Angelo A. Izzo.
Lipoxygenases: 15-LOX-2. Last modified on 04/03/2019. Accessed on 24/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1389.