<i>GPR162</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 142

Nomenclature: GPR162

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 588 12p13 GPR162 G protein-coupled receptor 162
Mouse 7 588 6 F2 Gpr162 G protein-coupled receptor 162
Rat 7 575 4q42 Gpr162 G protein-coupled receptor 162
Previous and Unofficial Names
Database Links
Specialist databases
GPCRDB gp162_human (Hs), gp162_mouse (Mm)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Tissue Distribution
Central nervous system, lung, sexual organs
Species:  Human
Technique:  Expressed sequence tag
References:  2
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  G450R
Global MAF (%):  3
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 6|2|3|3
Minor allele count:  A=0.032/70
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  R459G
Global MAF (%):  15
Subpopulation MAF (%):  AFR|AMR|EUR: 1|23|30
Minor allele count:  G=0.146/319
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
References:  1


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1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P et al.. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res., 14 (10B): 2121-7. [PMID:15489334]

2. Gloriam DE, Schiöth HB, Fredriksson R. (2005) Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Biochim. Biophys. Acta, 1722 (3): 235-46. [PMID:15777626]


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How to cite this page

Stephen P.H. Alexander, Jim Battey, Helen E. Benson, Richard V. Benya, Tom I. Bonner, Anthony P. Davenport, Anthony Harmar, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Wen Chiy Liew, Amy E. Monaghan, Chido Mpamhanga, Richard Neubig, Adam J. Pawson, Jean-Philippe Pin, Joanna L. Sharman, Michael Spedding, Eliot Spindel, Laura Storjohann, Kalyan Tirupula.
Class A Orphans: GPR162. Last modified on 16/06/2015. Accessed on 20/03/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=142.