Aminopeptidase N

Target id: 1560

Nomenclature: Aminopeptidase N

Family: M1: Aminopeptidase N

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Aminopeptidase N in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 967 15q25-q26 ANPEP alanyl aminopeptidase, membrane
Mouse - 966 7 D3 Anpep alanyl (membrane) aminopeptidase
Rat - 965 1q31 Anpep alanyl aminopeptidase, membrane
Previous and Unofficial Names
Alanyl aminopeptidase | gp150 | microsomal aminopeptidase | myeloid plasma membrane glycoprotein CD13 | LAP1 | AP-M | APN | aminopeptidase M | aminopeptidase N | cluster of differentiation antigen 13 (CD13) | kidney aminopeptidase M | kidney Zn peptidase | KZP | leucine arylaminopeptidase 1 | membrane alanine aminopeptidase | alanyl (membrane) aminopeptidase | alanyl aminopeptidase, membrane | alanyl aminopeptidase
Database Links
Specialist databases
MEROPS M01.001 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.11.2

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound I3 [PMID: 23428964] Hs Inhibition 9.5 pKi 3
pKi 9.5 (Ki 3.5x10-10 M) [3]
compound 1a [PMID: 25692029] Hs Inhibition 8.5 pKi 1-2
pKi 8.5 (Ki 2.9x10-9 M) [1-2]

References

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1. Bonnard E, Poras H, Nadal X, Maldonado R, Fournié-Zaluski MC, Roques BP. (2015) Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain. Pharmacol Res Perspect3 (2): e00116. [PMID:25692029]

2. Chen H, Noble F, Roques BP, Fournié-Zaluski MC. (2001) Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs. J. Med. Chem.44 (21): 3523-30. [PMID:11585456]

3. Schmitt C, Voegelin M, Marin A, Schmitt M, Schegg F, Hénon P, Guenot D, Tarnus C. (2013) Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy. Bioorg. Med. Chem.21 (7): 2135-44. [PMID:23428964]

How to cite this page

M1: Aminopeptidase N: Aminopeptidase N. Last modified on 05/04/2016. Accessed on 20/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1560.