Endoplasmic reticulum aminopeptidase 1

Target id: 1566

Nomenclature: Endoplasmic reticulum aminopeptidase 1

Family: M1: Aminopeptidase N

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Endoplasmic reticulum aminopeptidase 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 941 5q15 ERAP1 endoplasmic reticulum aminopeptidase 1
Mouse - 930 13 C1 Erap1 endoplasmic reticulum aminopeptidase 1
Rat - - 2q11 Erap1 endoplasmic reticulum aminopeptidase 1
Previous and Unofficial Names
Adipocyte-derived leucine aminopeptidase | puromycin-insensitive leucyl-specific aminopeptidase | aminopeptidase regulator of TNFR1 shedding | aminopeptidase PILS | Arts1 | ER-aminopeptidase 1 | leucyl-specific aminopeptidase PILS | ERAAP | A-LAP | ERAAP1 | PILS-AP
Database Links
Specialist databases
MEROPS M01.018 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.11.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 2g [PMID: 27390066] Hs Inhibition 6.3 pKi 2
pKi 6.3 (Ki 5.3x10-7 M) [2]
compound 3v [PMID: 27390066] Hs Inhibition <3.6 pKi 2
pKi <3.6 (Ki >2.5x10-4 M) [2]
compound 17 [PMID: 23916253] Hs Inhibition 5.6 pIC50 1
pIC50 5.6 (IC50 2.6x10-6 M) [1]


Show »

1. Papakyriakou A, Zervoudi E, Theodorakis EA, Saveanu L, Stratikos E, Vourloumis D. (2013) Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorg. Med. Chem. Lett.23 (17): 4832-6. [PMID:23916253]

2. Węglarz-Tomczak E, Vassiliou S, Mucha A. (2016) Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues. Bioorg. Med. Chem. Lett.26 (16): 4122-6. [PMID:27390066]

How to cite this page

M1: Aminopeptidase N: Endoplasmic reticulum aminopeptidase 1. Last modified on 20/10/2017. Accessed on 21/04/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1566.