Endoplasmic reticulum aminopeptidase 1 | M1: Aminopeptidase N | IUPHAR/BPS Guide to PHARMACOLOGY

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Endoplasmic reticulum aminopeptidase 1

Target not currently curated in GtoImmuPdb

Target id: 1566

Nomenclature: Endoplasmic reticulum aminopeptidase 1

Family: M1: Aminopeptidase N

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 941 5q15 ERAP1 endoplasmic reticulum aminopeptidase 1
Mouse - 930 13 C1 Erap1 endoplasmic reticulum aminopeptidase 1
Rat - - 2q11 Erap1 endoplasmic reticulum aminopeptidase 1
Previous and Unofficial Names
Adipocyte-derived leucine aminopeptidase | puromycin-insensitive leucyl-specific aminopeptidase | aminopeptidase regulator of TNFR1 shedding | aminopeptidase PILS | Arts1 | ER-aminopeptidase 1 | leucyl-specific aminopeptidase PILS | ERAAP | A-LAP | ERAAP1 | PILS-AP
Database Links
Specialist databases
MEROPS M01.018 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.11.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
compound 2g [PMID: 27390066] Hs Inhibition 6.3 pKi 2
pKi 6.3 (Ki 5.3x10-7 M) [2]
compound 3v [PMID: 27390066] Hs Inhibition <3.6 pKi 2
pKi <3.6 (Ki >2.5x10-4 M) [2]
compound 17 [PMID: 23916253] Hs Inhibition 5.6 pIC50 1
pIC50 5.6 (IC50 2.6x10-6 M) [1]


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1. Papakyriakou A, Zervoudi E, Theodorakis EA, Saveanu L, Stratikos E, Vourloumis D. (2013) Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorg. Med. Chem. Lett., 23 (17): 4832-6. [PMID:23916253]

2. Węglarz-Tomczak E, Vassiliou S, Mucha A. (2016) Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues. Bioorg. Med. Chem. Lett., 26 (16): 4122-6. [PMID:27390066]

How to cite this page

M1: Aminopeptidase N: Endoplasmic reticulum aminopeptidase 1. Last modified on 20/10/2017. Accessed on 27/05/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1566.