Endoplasmic reticulum aminopeptidase 1

Target id: 1566

Nomenclature: Endoplasmic reticulum aminopeptidase 1

Family: M1: Aminopeptidase N

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 941 5q15 ERAP1 endoplasmic reticulum aminopeptidase 1
Mouse - 930 13 C1 Erap1 endoplasmic reticulum aminopeptidase 1
Rat - - 2q11 Erap1 endoplasmic reticulum aminopeptidase 1
Previous and Unofficial Names
Adipocyte-derived leucine aminopeptidase
puromycin-insensitive leucyl-specific aminopeptidase
aminopeptidase regulator of TNFR1 shedding
aminopeptidase PILS
Arts1
ER-aminopeptidase 1
leucyl-specific aminopeptidase PILS
ERAAP
A-LAP
ERAAP1
PILS-AP
Database Links
Specialist databases
MEROPS M01.018 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
ExplorEnz
GeneCards
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
InterPro
KEGG Enzyme
KEGG Gene
NeXtProt
OMIM
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.11.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 17 [PMID: 23916253] Hs Inhibition 5.6 pIC50 1
pIC50 5.6 (IC50 2.6x10-6 M) [1]

References

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1. Papakyriakou A, Zervoudi E, Theodorakis EA, Saveanu L, Stratikos E, Vourloumis D. (2013) Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorg. Med. Chem. Lett.23 (17): 4832-6. [PMID:23916253]

How to cite this page

M1: Aminopeptidase N: Endoplasmic reticulum aminopeptidase 1. Last modified on 28/07/2015. Accessed on 04/09/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1566.