Endoplasmic reticulum aminopeptidase 2

Target id: 1567

Nomenclature: Endoplasmic reticulum aminopeptidase 2

Family: M1: Aminopeptidase N

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Endoplasmic reticulum aminopeptidase 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 960 5q15 ERAP2 endoplasmic reticulum aminopeptidase 2
Previous and Unofficial Names
L-RAP | Leukocyte-derived arginine aminopeptidase
Database Links
Specialist databases
MEROPS M01.024 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.11.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 2g [PMID: 27390066] Hs Inhibition 6.8 pKi 2
pKi 6.8 (Ki 1.5x10-7 M) [2]
compound 3v [PMID: 27390066] Hs Inhibition 6.2 pKi 2
pKi 6.2 (Ki 6.2x10-7 M) [2]
compound 17 [PMID: 23916253] Hs Inhibition 5.1 pIC50 1
pIC50 5.1 (IC50 8.9x10-6 M) [1]

References

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1. Papakyriakou A, Zervoudi E, Theodorakis EA, Saveanu L, Stratikos E, Vourloumis D. (2013) Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorg. Med. Chem. Lett.23 (17): 4832-6. [PMID:23916253]

2. Węglarz-Tomczak E, Vassiliou S, Mucha A. (2016) Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues. Bioorg. Med. Chem. Lett.26 (16): 4122-6. [PMID:27390066]

How to cite this page

M1: Aminopeptidase N: Endoplasmic reticulum aminopeptidase 2. Last modified on 20/10/2017. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1567.