Glutamyl aminopeptidase

Target id: 1568

Nomenclature: Glutamyl aminopeptidase

Family: M1: Aminopeptidase N

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 957 4q25 ENPEP glutamyl aminopeptidase (aminopeptidase A)
Mouse - 945 3 G3 Enpep glutamyl aminopeptidase
Rat - - 2q42 Enpep glutamyl aminopeptidase
Previous and Unofficial Names
differentiation antigen gp160
EAP
APA
Ly51
CD249
gp160
Database Links
Specialist databases
MEROPS M01.003 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
ExplorEnz
GeneCards
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
InterPro
KEGG Enzyme
KEGG Gene
NeXtProt
OMIM
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.11.7

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 40 [PMID: 10602705] Mm Inhibition 9.1 pKi 1
pKi 9.1 (Ki 8.73x10-10 M) [1]

References

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1. David C, Bischoff L, Meudal H, Mothé A, De Mota N, DaNascimento S, Llorens-Cortes C, Fournié-Zaluski MC, Roques BP. (1999) Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme. J. Med. Chem.42 (25): 5197-211. [PMID:10602705]

How to cite this page

M1: Aminopeptidase N: Glutamyl aminopeptidase. Last modified on 22/07/2015. Accessed on 02/09/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1568.