Leucine aminopeptidase 3

Target id: 1569

Nomenclature: Leucine aminopeptidase 3

Family: M17: Leucyl aminopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Leucine aminopeptidase 3 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 519 4p15.33 LAP3 leucine aminopeptidase 3
Mouse - 519 5 B3 Lap3 leucine aminopeptidase 3
Rat - 519 14q21 Lap3 leucine aminopeptidase 3
Previous and Unofficial Names
LAP | LAPEP | peptidase S | cytosol aminopeptidase | LAP-3 | leucine aminopeptidase 3 | proline aminopeptidase | prolyl aminopeptidase | Pep7 | PEPS
Database Links
Specialist databases
MEROPS M17.001 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.11.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
bestatin Bt Inhibition 9.2 pKi 1-2
pKi 9.2 (Ki 6x10-10 M) [1-2]

References

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1. Grembecka J, Mucha A, Cierpicki T, Kafarski P. (2003) The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity. J. Med. Chem.46 (13): 2641-55. [PMID:12801228]

2. Taylor A, Peltier CZ, Torre FJ, Hakamian N. (1993) Inhibition of bovine lens leucine aminopeptidase by bestatin: number of binding sites and slow binding of this inhibitor. Biochemistry32 (3): 784-90. [PMID:8422382]

How to cite this page

M17: Leucyl aminopeptidase: Leucine aminopeptidase 3. Last modified on 22/07/2015. Accessed on 11/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1569.