Methionyl aminopeptidase 2

Target id: 1573

Nomenclature: Methionyl aminopeptidase 2

Family: M24: Methionyl aminopeptidase

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Methionyl aminopeptidase 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 478 12q22 METAP2 methionyl aminopeptidase 2
Mouse - 478 10 C2 Metap2 methionine aminopeptidase 2
Rat - 478 7q13 Metap2 methionyl aminopeptidase 2
Previous and Unofficial Names
initiation factor 2 associated 67 kDa protein | metAP 2 | methionine aminopeptidase 2 | peptidase M 2 | eIF-2-associated p67 | MAP2 | MNPEP
Database Links
Specialist databases
MEROPS M24.002 (Hs)
Other databases
BRENDA
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.11.18

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
XMT-1191 Hs Inhibition 8.0 pIC50 1
pIC50 8.0 (IC50 9x10-9 M) [1]
beloranib Hs Inhibition - - 2
[2]

References

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1. Akullian LC, Stevenson CA, Yurkovetskiy AV, Benson JD, Fram RJ, Lowinger TB. (2009) Anti-angiogenic and Anti-tumor Activity of XMT-1107, a Fumagillol-derived Polymer Conjugate, and its in vivo Release Product XMT-1191. Proc Am Assoc Cancer Res., : 670.

2. Kim YM, An JJ, Jin YJ, Rhee Y, Cha BS, Lee HC, Lim SK. (2007) Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732. J. Mol. Endocrinol.38 (4): 455-65. [PMID:17446235]

How to cite this page

M24: Methionyl aminopeptidase: Methionyl aminopeptidase 2. Last modified on 16/06/2015. Accessed on 15/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1573.