X-prolyl aminopeptidase 2 | M24: Methionyl aminopeptidase | IUPHAR/BPS Guide to PHARMACOLOGY

X-prolyl aminopeptidase 2

Target id: 1579

Nomenclature: X-prolyl aminopeptidase 2

Family: M24: Methionyl aminopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for X-prolyl aminopeptidase 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 674 Xq25 XPNPEP2 X-prolyl aminopeptidase 2
Mouse - 674 X A3.2 Xpnpep2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
Rat - 674 Xq35 Xpnpep2 X-prolyl aminopeptidase 2
Previous and Unofficial Names
Aminopeptidase P 2 | membrane-bound X-prolyl aminopeptidase | mAPP | X-prolyl aminopeptidase (aminopeptidase P) 2
Database Links
Specialist databases
MEROPS M24.005 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.11.9

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
apstatin Hs Inhibition 6.2 pKi 1
pKi 6.2 (Ki 6.4x10-7 M) [1]
compound 6 [PMID: 10395480] Hs Inhibition 6.6 pIC50 1
pIC50 6.6 (IC50 2.3x10-7 M) [1]
apstatin Hs Inhibition 5.5 pIC50 1
pIC50 5.5 (IC50 2.9x10-6 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Angioedema induced by ACE inhibitors, susceptibility to; AEACEI
Synonyms: Renin-angiotensin-aldosterone system-blocker-induced angioedema [Orphanet: ORPHA100057]
OMIM: 300909
Orphanet: ORPHA100057

References

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1. Maggiora LL, Orawski AT, Simmons WH. (1999) Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J. Med. Chem., 42 (13): 2394-402. [PMID:10395480]

How to cite this page

M24: Methionyl aminopeptidase: X-prolyl aminopeptidase 2. Last modified on 18/09/2015. Accessed on 13/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1579.