<i>OPN5</i> | Opsin receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 161

Nomenclature: OPN5

Family: Opsin receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 354 6p12.3 OPN5 opsin 5 1,7
Mouse 7 377 17 B3 Opn5 opsin 5 1,7
Rat 7 534 9q12 Opn5 opsin 5
Previous and Unofficial Names
opsin 5 | transmembrane protein 13 | GPR136 | PGR12 | neuropsin | PGR14 | TMEM13 | G protein-coupled receptor 136
Database Links
Specialist databases
GPCRDB opn5_human (Hs), opn5_mouse (Mm), q7tqn6_rat (Rn)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family
Comments:  Evidence indicates OPN5 triggers a UV-sensitive Gi-mediated signalling pathway in mammalian tissues [4].
References:  4
Tissue Distribution
Retina, brain, testis
Species:  Human
Technique:  RT-PCR
References:  7
Eye, brain, testis
Species:  Mouse
Technique:  RT-PCR
References:  7
Retina (non-rod non-cone retinal neurons), brain, outer ears (epidermal and muscle cells)
Species:  Mouse
Technique:  Immunohistochemistry
References:  4
Retina (inner plexiform layer, inner nuclear layer)
Species:  Rat
Technique:  Immunohistochemistry
References:  6
Tissue Distribution Comments
The human Müller cell line MIO-M1 expresses OPN5 [2].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Clinically-Relevant Mutations and Pathophysiology Comments
Association studies suggested that genetic variation of OPN5 may contribute to the molecular mechanisms of bipolar disorder, and some aspects of memory and intelligence [3].
General Comments
OPN5 has been identified as a deep brain photoreceptor in birds [5]. Human and mouse OPN5 have a maximum UV absorption at 380nm, indicating that the receptor is the first human opsin with a peak sensitivity in the UV region [4].


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1. Fornai F, Lenzi P, Gesi M, Ferrucci M, Lazzeri G, Busceti CL, Ruffoli R, Soldani P, Ruggieri S, Alessandri MG et al.. (2003) Fine structure and biochemical mechanisms underlying nigrostriatal inclusions and cell death after proteasome inhibition. J. Neurosci., 23 (26): 8955-66. [PMID:14523098]

2. Hollborn M, Ulbricht E, Rillich K, Dukic-Stefanovic S, Wurm A, Wagner L, Reichenbach A, Wiedemann P, Limb GA, Bringmann A et al.. (2011) The human Müller cell line MIO-M1 expresses opsins. Mol. Vis., 17: 2738-50. [PMID:22065927]

3. Izumi A, Iijima Y, Noguchi H, Numakawa T, Okada T, Hori H, Kato T, Tatsumi M, Kosuga A, Kamijima K et al.. (2008) Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions. Neuropsychopharmacology, 33 (13): 3237-45. [PMID:18354391]

4. Kojima D, Mori S, Torii M, Wada A, Morishita R, Fukada Y. (2011) UV-sensitive photoreceptor protein OPN5 in humans and mice. PLoS ONE, 6 (10): e26388. [PMID:22043319]

5. Nakane Y, Ikegami K, Ono H, Yamamoto N, Yoshida S, Hirunagi K, Ebihara S, Kubo Y, Yoshimura T. (2010) A mammalian neural tissue opsin (Opsin 5) is a deep brain photoreceptor in birds. Proc. Natl. Acad. Sci. U.S.A., 107 (34): 15264-8. [PMID:20679218]

6. Nieto PS, Valdez DJ, Acosta-Rodríguez VA, Guido ME. (2011) Expression of novel opsins and intrinsic light responses in the mammalian retinal ganglion cell line RGC-5. Presence of OPN5 in the rat retina. PLoS ONE, 6 (10): e26417. [PMID:22022612]

7. Tarttelin EE, Bellingham J, Hankins MW, Foster RG, Lucas RJ. (2003) Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. FEBS Lett., 554 (3): 410-6. [PMID:14623103]

How to cite this page

Opsin receptors: OPN5. Last modified on 30/10/2017. Accessed on 19/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=161.