MMP10

Target id: 1634

Nomenclature: MMP10

Family: M10: Matrix metallopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for MMP10 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 476 11q22.3 MMP10 matrix metallopeptidase 10
Mouse - 476 9 A1 Mmp10 matrix metallopeptidase 10
Rat - 476 8q11 Mmp10 matrix metallopeptidase 10
Previous and Unofficial Names
transin-2 | SL-2 | transformation-associated protein 34A | STMY2 | matrix metallopeptidase 10 (stromelysin 2)
Database Links
Specialist databases
MEROPS M10.006 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.24.22

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
CM-352 Hs Inhibition 7.8 pIC50 1
pIC50 7.8 (IC50 1.5x10-8 M) [1]

References

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1. Orbe J, Rodríguez JA, Sánchez-Arias JA, Salicio A, Belzunce M, Ugarte A, Chang HC, Rabal O, Oyarzabal J, Páramo JA. (2015) Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the prevention and treatment of hemorrhage. J. Med. Chem., 58 (7): 2941-57. [PMID:25686022]

How to cite this page

M10: Matrix metallopeptidase: MMP10. Last modified on 29/08/2017. Accessed on 22/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1634.