<i>P2RY10</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 165

Nomenclature: P2RY10

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 339 Xq21.1 P2RY10 P2Y receptor family member 10
Mouse 7 328 X D P2ry10 purinergic receptor P2Y
Rat 7 388 Xq31 P2ry10 P2Y receptor family member 10
Previous and Unofficial Names
purinergic receptor P2Y10 | purinergic receptor P2Y, G-protein coupled 10 | purinergic receptor P2Y
Database Links
Specialist databases
GPCRDB p2y10_human (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Natural/Endogenous Ligands
sphingosine 1-phosphate
Comments: Proposed ligands, single publication

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
sphingosine 1-phosphate Hs Agonist 7.3 pEC50 2
pEC50 7.3 [2]
LPA Hs Agonist 6.9 pEC50 2
pEC50 6.9 [2]
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
dioctanoylglycerol pyrophosphate Hs Antagonist - - 2
JTE-013 Hs Antagonist - - 2
Tissue Distribution
Expression level:  High
Species:  Human
Technique:  qRT-PCR (microarray analysis) and western blotting
References:  1
Expression level:  High
Species:  Mouse
Technique:  Northern blot, subtractive hybridisation
References:  3
Placenta, uterus, prostate, brain, lung, and skeletal muscle
Expression level:  High
Species:  Mouse
Technique:  RT-PCR
References:  2
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  N3H
Global MAF (%):  19
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 7|24|49|1
Minor allele count:  C=0.187/311
SNP accession: 
Validation:  1000 Genomes, HapMap


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1. Amisten S, Braun OO, Bengtsson A, Erlinge D. (2008) Gene expression profiling for the identification of G-protein coupled receptors in human platelets. Thromb. Res., 122 (1): 47-57. [PMID:17920662]

2. Murakami M, Shiraishi A, Tabata K, Fujita N. (2008) Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem. Biophys. Res. Commun., 371 (4): 707-12. [PMID:18466763]

3. Rao S, Garrett-Sinha LA, Yoon J, Simon MC. (1999) The Ets factors PU.1 and Spi-B regulate the transcription in vivo of P2Y10, a lymphoid restricted heptahelical receptor. J. Biol. Chem., 274 (48): 34245-52. [PMID:10567398]


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How to cite this page

Stephen P.H. Alexander, Jim Battey, Helen E. Benson, Richard V. Benya, Tom I. Bonner, Anthony P. Davenport, Satoru Eguchi, Anthony Harmar, Nick Holliday, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Wen Chiy Liew, Amy E. Monaghan, Chido Mpamhanga, Richard Neubig, Adam J. Pawson, Jean-Philippe Pin, Joanna L. Sharman, Michael Spedding, Eliot Spindel, Leigh Stoddart, Laura Storjohann, Walter (Wally) Thomas, Kalyan Tirupula, Patrick Vanderheyden.
Class A Orphans: P2RY10. Last modified on 31/08/2015. Accessed on 24/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=165.