<i>P2RY10</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

P2RY10

Target id: 165

Nomenclature: P2RY10

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for P2RY10 in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 339 Xq21.1 P2RY10 P2Y receptor family member 10
Mouse 7 328 X D P2ry10 purinergic receptor P2Y, G-protein coupled 10
Rat 7 388 Xq31 P2ry10 P2Y receptor family member 10
Previous and Unofficial Names
purinergic receptor P2Y10 | purinergic receptor P2Y, G-protein coupled 10 | purinergic receptor P2Y
Database Links
Specialist databases
GPCRDB p2y10_human (Hs)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
LPA
sphingosine 1-phosphate
Comments: Proposed ligands, single publication

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
sphingosine 1-phosphate Hs Agonist 7.3 pEC50 2
pEC50 7.3 [2]
LPA Hs Agonist 6.9 pEC50 2
pEC50 6.9 [2]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
dioctanoylglycerol pyrophosphate Hs Antagonist - - 2
[2]
JTE-013 Hs Antagonist - - 2
[2]
Tissue Distribution
Platelets
Expression level:  High
Species:  Human
Technique:  qRT-PCR (microarray analysis) and western blotting
References:  1
B-cells
Expression level:  High
Species:  Mouse
Technique:  Northern blot, subtractive hybridisation
References:  3
Placenta, uterus, prostate, brain, lung, and skeletal muscle
Expression level:  High
Species:  Mouse
Technique:  RT-PCR
References:  2
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  N3H
Global MAF (%):  19
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 7|24|49|1
Minor allele count:  C=0.187/311
SNP accession: 
Validation:  1000 Genomes, HapMap

References

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1. Amisten S, Braun OO, Bengtsson A, Erlinge D. (2008) Gene expression profiling for the identification of G-protein coupled receptors in human platelets. Thromb. Res., 122 (1): 47-57. [PMID:17920662]

2. Murakami M, Shiraishi A, Tabata K, Fujita N. (2008) Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem. Biophys. Res. Commun., 371 (4): 707-12. [PMID:18466763]

3. Rao S, Garrett-Sinha LA, Yoon J, Simon MC. (1999) The Ets factors PU.1 and Spi-B regulate the transcription in vivo of P2Y10, a lymphoid restricted heptahelical receptor. J. Biol. Chem., 274 (48): 34245-52. [PMID:10567398]

Contributors

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How to cite this page

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: P2RY10. Last modified on 31/08/2015. Accessed on 14/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=165.