ADAM12

Target id: 1660

Nomenclature: ADAM12

Family: M12: Astacin/Adamalysin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ADAM12 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 909 10q26 ADAM12 ADAM metallopeptidase domain 12
Mouse - 903 7 F4 Adam12 a disintegrin and metallopeptidase domain 12 (meltrin alpha)
Rat - - 1q41 Adam12 ADAM metallopeptidase domain 12
Previous and Unofficial Names
MCMPMltna | MLTN
Database Links
Specialist databases
MEROPS M12.212 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ilomastat Hs Inhibition 8.2 pIC50 1
pIC50 8.2 (IC50 5.93x10-9 M) [1]
Description: Measured in a cell-based assay.

References

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1. Oh M, Im I, Lee YJ, Kim YH, Yoon JH, Park HG, Higashiyama S, Kim YC, Park WJ. (2004) Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors. Bioorg. Med. Chem. Lett.14 (24): 6071-4. [PMID:15546732]

How to cite this page

M12: Astacin/Adamalysin: ADAM12. Last modified on 29/07/2015. Accessed on 19/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1660.