Target id: 1660

Nomenclature: ADAM12

Family: M12: Astacin/Adamalysin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ADAM12 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 909 10q26 ADAM12 ADAM metallopeptidase domain 12
Mouse - 903 7 F4 Adam12 a disintegrin and metallopeptidase domain 12 (meltrin alpha)
Rat - - 1q41 Adam12 ADAM metallopeptidase domain 12
Previous and Unofficial Names
Database Links
Specialist databases
MEROPS M12.212 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ilomastat Hs Inhibition 8.2 pIC50 1
pIC50 8.2 (IC50 5.93x10-9 M) [1]
Description: Measured in a cell-based assay.


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1. Oh M, Im I, Lee YJ, Kim YH, Yoon JH, Park HG, Higashiyama S, Kim YC, Park WJ. (2004) Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors. Bioorg. Med. Chem. Lett.14 (24): 6071-4. [PMID:15546732]

How to cite this page

M12: Astacin/Adamalysin: ADAM12. Last modified on 29/07/2015. Accessed on 18/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY,