<i>TAAR2</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

TAAR2

Target id: 167

Nomenclature: TAAR2

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for TAAR2 in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 351 6q23.2 TAAR2 trace amine associated receptor 2 (gene/pseudogene) 6
Mouse 7 339 10 A4 Taar2 trace amine-associated receptor 2
Rat 7 339 1p12 Taar2 trace amine associated receptor 2
Previous and Unofficial Names
GPR58 | G protein-coupled receptor 58 | trace amine receptor 2
Database Links
Specialist databases
GPCRDB taar2_human (Hs), taar2_mouse (Mm), taar2_rat (Rn)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Potency order of endogenous ligands
β-phenylethylamine > tryptamine  [2]
Primary Transduction Mechanisms
Comments:  TAAR2 is found to be coexpressed with Gα proteins. However, the transduction pathway of TAAR2 is yet to be determined.
References:  7
Tissue Distribution
Olfactory epithelium
Species:  Mouse
Technique:  RT-PCR and in situ hybridisation.
References:  7
Cells of Grueneberg ganglion
Species:  Mouse
Technique:  in situ hybridisation
References:  4
Mucosal layer of gastrointestinal tract, predominantly in duodenum.
Species:  Mouse
Technique:  RT-PCR
References:  5
Heart
Species:  Rat
Technique: 
References:  8
Tissue Distribution Comments
No TAAR2 mRNAs were detected by Northern blot analysis in the pons, thalamus, hypothalamus, hippocampus, caudate, putamen, frontal cortex, basal forebrain, midbrain and liver [6].
Expression Datasets

Show »

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Clinically-Relevant Mutations and Pathophysiology Comments
A SNP nonsense mutation in the TAAR2 gene has been associated with schizophrenia [1].
Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  F131L
Global MAF (%):  17
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 49|11|11|3
Minor allele count:  A=0.167/365
SNP accession: 
Validation:  1000 Genomes, Frequency, Cluster
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  R43Q
Global MAF (%):  3
Subpopulation MAF (%):  AFR|AMR: 14|1
Minor allele count:  T=0.034/75
SNP accession: 
Validation:  1000 Genomes, Frequency, Cluster
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S85F
Global MAF (%):  3
Subpopulation MAF (%):  AFR|AMR: 14|1
Minor allele count:  A=0.034/75
SNP accession: 
Validation:  1000 Genomes, Frequency, Cluster
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S130F
SNP accession: 
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  W168X
Comment on frequency:  Found in 10-15% of Asian population
SNP accession: 
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S85F
Comment on frequency:  Low frequency (<10% in tested population)
SNP accession: 
General Comments
Probable pseudogene in 10–15% of Asians due to a polymorphism (rs8192646) producing a premature stop codon at amino acid 168 [3].

References

Show »

1. Bly M. (2005) Examination of the trace amine-associated receptor 2 (TAAR2). Schizophr. Res., 80 (2-3): 367-8. [PMID:15993565]

2. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci U S A, 98: 8966-8971. [PMID:11459929]

3. Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR et al.. (2013) International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol. Rev., 65 (3): 967-86. [PMID:23686350]

4. Fleischer J, Schwarzenbacher K, Breer H. (2007) Expression of trace amine-associated receptors in the Grueneberg ganglion. Chem. Senses, 32 (6): 623-31. [PMID:17556730]

5. Ito J, Ito M, Nambu H, Fujikawa T, Tanaka K, Iwaasa H, Tokita S. (2009) Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice. Cell Tissue Res., 338 (2): 257-69. [PMID:19763624]

6. Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng HH, Seeman P, George SR, O'Dowd BF, Marchese A. (2000) Cloning and characterization of additional members of the G protein-coupled receptor family. Biochim. Biophys. Acta, 1490 (3): 311-23. [PMID:10684976]

7. Liberles SD, Buck LB. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

8. Zucchi R, Chiellini G, Scanlan TS, Grandy DK. (2006) Trace amine-associated receptors and their ligands. Br J Pharmacol, 149: 967-978. [PMID:17088868]

Contributors

Show »

How to cite this page

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: TAAR2. Last modified on 25/06/2015. Accessed on 17/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=167.