phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

Target id: 2150

Nomenclature: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

Abbreviated Name: C2α/PIK3C2A

Family: Phosphatidylinositol-4-phosphate 3-kinase family, Phosphatidylinositol kinases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1686 11p15.5-p14 PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Mouse - 1686 7 F1 Pik3c2a phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Rat - 1687 1 q34-q35 Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Previous and Unofficial Names
Phosphoinositide 3-kinase-C2-alpha | phosphoinositide-3-kinase, class 2, alpha polypeptide | PI3KC2 | PI3K-C2alpha | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | phosphatidylinositol-4-phosphate 3-kinase
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structures of C2ALPHA-PI3 kinase PX-domain domain indicate conformational change associated with ligand binding.
PDB Id:  2RED
Resolution:  2.1Å
Species:  Human
References:  2
Enzyme Reaction
EC Number: 2.7.1.154

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
torin 2 Hs Inhibition 7.6 pIC50 1
pIC50 7.6 (IC50 2.81x10-8 M) [1]

References

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1. Liu Q, Wang J, Kang SA, Thoreen CC, Hur W, Ahmed T, Sabatini DM, Gray NS. (2011) Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. J. Med. Chem.54 (5): 1473-80. [PMID:21322566]

2. Parkinson GN, Vines D, Driscoll PC, Djordjevic S. (2008) Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding. BMC Struct. Biol.8: 13. [PMID:18312637]

How to cite this page

Phosphatidylinositol kinases: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha. Last modified on 29/01/2016. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2150.