sphingosine kinase 2 | Sphingosine kinase | IUPHAR/BPS Guide to PHARMACOLOGY

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sphingosine kinase 2

Target not currently curated in GtoImmuPdb

Target id: 2205

Nomenclature: sphingosine kinase 2

Abbreviated Name: SPHK2

Family: Sphingosine kinase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 654 19q13.2 SPHK2 sphingosine kinase 2
Mouse - 617 7 B4 Sphk2 sphingosine kinase 2
Rat - 616 1 q22 Sphk2 sphingosine kinase 2
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: Sphingosine + ATP = sphingosine 1-phosphate + ADP
ATP + sphinganine = sphinganine 1-phosphate + ADP
Cofactor Species Comments Reference
Mg2+ None

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
ABC294640 Hs Inhibition 5.0 pKi 1
pKi 5.0 (Ki 9.8x10-6 M) [1]
ROMe Hs Inhibition 4.6 pIC50 2
pIC50 4.6 (IC50 2.7x10-5 M) [2]


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1. French KJ, Zhuang Y, Maines LW, Gao P, Wang W, Beljanski V, Upson JJ, Green CL, Keller SN, Smith CD. (2010) Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. J. Pharmacol. Exp. Ther., 333 (1): 129-39. [PMID:20061445]

2. Lim KG, Sun C, Bittman R, Pyne NJ, Pyne S. (2011) (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cell. Signal., 23 (10): 1590-5. [PMID:21620961]

How to cite this page

Sphingosine kinase: sphingosine kinase 2. Last modified on 21/10/2015. Accessed on 19/03/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2205.