Interleukin-12 receptor

Target id: 2292

Nomenclature: Interleukin-12 receptor

Family: IL-12 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-12 receptor has curated GtoImmuPdb data

Quaternary Structure: Subunits
Interleukin-12 receptor, β1 subunit (Ligand-binding subunit)
Interleukin-12 receptor, β2 subunit (Other subunit)

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Agonists
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Ligand Sp. Action Affinity Units Reference
IL-12 {Sp: Human} Hs Agonist - -
Immunopharmacology Comments
This is the type I cytokine receptor for interleukin 12 (IL-12). It is a heterodimeric receptor formed by IL-12R-β1 (IL12RB1; ligand binding subunit) and IL-12R-β2 (IL12RB2). IL-12R signals via the JAK-STAT pathway. IL-12 receptor activation promotes the development of Th1 responses and induces IFNγ production by T and NK cells. Patients with inactive IL-12 receptors exhibit impaired mycobacterial immunity, with a failure to produce an IFNγ response to IL-12 [1].

References

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1. Altare F, Durandy A, Lammas D, Emile JF, Lamhamedi S, Le Deist F, Drysdale P, Jouanguy E, Döffinger R, Bernaudin F et al.. (1998) Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science280 (5368): 1432-5. [PMID:9603732]

How to cite this page

IL-12 receptor family: Interleukin-12 receptor. Last modified on 22/03/2017. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2292.