bone morphogenetic protein 1 | M12: Astacin/Adamalysin | IUPHAR/BPS Guide to PHARMACOLOGY

bone morphogenetic protein 1

Target id: 2333

Nomenclature: bone morphogenetic protein 1

Family: M12: Astacin/Adamalysin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for bone morphogenetic protein 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 986 8p21 BMP1 bone morphogenetic protein 1
Mouse - 991 14 D2 Bmp1 bone morphogenetic protein 1
Rat - 990 15p11 Bmp1 bone morphogenetic protein 1
Previous and Unofficial Names
mammalian tolloid protein | PCOLC | Pcp | procollagen C-proteinase | Tld | procollagen C-endopeptidase
Database Links
Specialist databases
MEROPS M12.005 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.24.19

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 2 [PMID: 11934595] Hs Inhibition 6.7 pIC50 1
pIC50 6.7 (IC50 2x10-7 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Osteogenesis imperfecta, type XIII
OMIM: 614856

References

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1. Dankwardt SM, Abbot SC, Broka CA, Martin RL, Chan CS, Springman EB, Van Wart HE, Walker KA. (2002) Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains. Bioorg. Med. Chem. Lett., 12 (8): 1233-5. [PMID:11934595]

How to cite this page

M12: Astacin/Adamalysin: bone morphogenetic protein 1. Last modified on 14/07/2015. Accessed on 24/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2333.