bone morphogenetic protein 1

Target id: 2333

Nomenclature: bone morphogenetic protein 1

Family: M12: Astacin/Adamalysin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for bone morphogenetic protein 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 986 8p21 BMP1 bone morphogenetic protein 1
Mouse - 991 14 D2 Bmp1 bone morphogenetic protein 1
Rat - 990 15p11 Bmp1 bone morphogenetic protein 1
Previous and Unofficial Names
mammalian tolloid protein | PCOLC | Pcp | procollagen C-proteinase | Tld | procollagen C-endopeptidase
Database Links
Specialist databases
MEROPS M12.005 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 2 [PMID: 11934595] Hs Inhibition 6.7 pIC50 1
pIC50 6.7 (IC50 2x10-7 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Osteogenesis imperfecta, type XIII
OMIM: 614856


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1. Dankwardt SM, Abbot SC, Broka CA, Martin RL, Chan CS, Springman EB, Van Wart HE, Walker KA. (2002) Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains. Bioorg. Med. Chem. Lett.12 (8): 1233-5. [PMID:11934595]

How to cite this page

M12: Astacin/Adamalysin: bone morphogenetic protein 1. Last modified on 14/07/2015. Accessed on 23/02/2018. IUPHAR/BPS Guide to PHARMACOLOGY,