chymase 1

Target id: 2340

Nomenclature: chymase 1

Family: S1: Chymotrypsin

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for chymase 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 247 14q12 CMA1 chymase 1
Mouse - 260 14 C3 Cma1 chymase 1, mast cell
Rat - 247 15p13 Cma1 chymase 1
Previous and Unofficial Names
alpha-chymase | chymase 1, mast cell | mast cell protease 3 | mast cell protease 5 | mast cell protease I | mast cell protease III | MCP3P | Mcp5
Database Links
Specialist databases
MEROPS S01.140 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.39

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
NK3201 Hs Inhibition 8.6 pIC50 2
pIC50 8.6 (IC50 2.5x10-9 M) [2]
JNJ-10311795 Hs Inhibition 8.3 pIC50 1
pIC50 8.3 (IC50 4.5x10-9 M) [1]

References

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1. Greco MN, Hawkins MJ, Powell ET, Almond Jr HR, de Garavilla L, Hall J, Minor LK, Wang Y, Corcoran TW, Di Cera E et al.. (2007) Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J. Med. Chem.50 (8): 1727-30. [PMID:17361995]

2. Tsunemi K, Takai S, Nishimoto M, Jin D, Sakaguchi M, Muramatsu M, Yuda A, Sasaki S, Miyazaki M. (2004) A specific chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide (NK3201), suppresses development of abdominal aortic aneurysm in hamsters. J. Pharmacol. Exp. Ther.309 (3): 879-83. [PMID:14960660]

How to cite this page

S1: Chymotrypsin: chymase 1. Last modified on 30/03/2016. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2340.