cathepsin F | C1: Papain | IUPHAR/BPS Guide to PHARMACOLOGY

cathepsin F

Target id: 2347

Nomenclature: cathepsin F

Family: C1: Papain

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for cathepsin F in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 484 11q13.2 CTSF cathepsin F
Mouse - 462 19 A Ctsf cathepsin F
Rat - 462 1q43 Ctsf cathepsin F
Previous and Unofficial Names
CATSF | CLN13
Database Links
Specialist databases
MEROPS C01.018 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.22.41

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound (R)-26 [PMID: 22686657] Hs Inhibition 7.7 pKi 1
pKi 7.7 (Ki 2.1x10-8 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Ceroid lipofuscinosis, neuronal, 13
Synonyms: CLN13 disease [Orphanet: ORPHA352709]
Neuronal ceroid lipofuscinosis [Disease Ontology: DOID:14503]
Disease Ontology: DOID:14503
OMIM: 615362
Orphanet: ORPHA352709

References

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1. Frizler M, Schmitz J, Schulz-Fincke AC, Gütschow M. (2012) Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F. J. Med. Chem., 55 (12): 5982-6. [PMID:22686657]

How to cite this page

C1: Papain: cathepsin F. Last modified on 23/07/2015. Accessed on 15/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2347.