coagulation factor XI

Target id: 2360

Nomenclature: coagulation factor XI

Family: S1: Chymotrypsin

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for coagulation factor XI in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 625 4q35 F11 coagulation factor XI
Mouse - 624 8 B1.1 F11 coagulation factor XI
Rat - 556 16q11 F11 coagulation factor XI
Previous and Unofficial Names
Cf11 | FXI | plasma thromboplastin antecedent | PTA
Database Links
Specialist databases
MEROPS S01.213 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
alpha-ketothiazole analogue 36 Hs Inhibition 7.5 pIC50 1
pIC50 7.5 (IC50 3x10-8 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Factor XI deficiency
Disease Ontology: DOID:2229
OMIM: 612416
Orphanet: ORPHA329


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1. Maryanoff BE, Costanzo MJ. (2008) Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg. Med. Chem.16 (4): 1562-95. [PMID:18053726]

How to cite this page

S1: Chymotrypsin: coagulation factor XI. Last modified on 07/03/2014. Accessed on 22/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY,