kallikrein related peptidase 3

Target id: 2373

Nomenclature: kallikrein related peptidase 3

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for kallikrein related peptidase 3 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 261 19q13.41 KLK3 kallikrein related peptidase 3
Mouse - 263 7 B4 Klk1b27 kallikrein 1-related peptidase b27
Previous and Unofficial Names
APS | Gk27 | glandular kallikrein 27 | kallikrein 27 | Prostate-specific antigen | PSA | tissue kallikrein 27 | kallikrein-related peptidase 3
Database Links
Specialist databases
MEROPS S01.162 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.77

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 20 [PMID: 23692593] Hs Inhibition 7.1 pKi 1
pKi 7.1 (Ki 7.2x10-8 M) [1]
Description: PSA isolated from human seminal plasma.

References

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1. Kostova MB, Rosen DM, Chen Y, Mease RC, Denmeade SR. (2013) Structural optimization, biological evaluation, and application of peptidomimetic prostate specific antigen inhibitors. J. Med. Chem.56 (11): 4224-35. [PMID:23692593]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 3. Last modified on 29/01/2016. Accessed on 11/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2373.