kallikrein related peptidase 6 | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

kallikrein related peptidase 6

Target id: 2376

Nomenclature: kallikrein related peptidase 6

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for kallikrein related peptidase 6 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 244 19q13.3 KLK6 kallikrein related peptidase 6
Mouse - 253 7 B4-B5 Klk6 kallikrein related-peptidase 6
Rat - 251 1q22 Klk6 kallikrein related-peptidase 6
Previous and Unofficial Names
brain serine protease | BSP | kallikrein 29 | kallikrein 6 | Klk29 | Klk7 | MSP | myelencephalon-specific protease | neurosin | protease serine 9 | protease, serine, 18 | Prss18 | Prss9 | kallikrein-related peptidase 6
Database Links
Specialist databases
MEROPS S01.236 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 5 {PMID: 24900446] Hs Inhibition 5.8 pIC50 1
pIC50 5.8 (IC50 1.5x10-6 M) [1]


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1. Liang G, Chen X, Aldous S, Pu SF, Mehdi S, Powers E, Giovanni A, Kongsamut S, Xia T, Zhang Y et al.. (2012) Virtual Screening and X-ray Crystallography for Human Kallikrein 6 Inhibitors with an Amidinothiophene P1 Group. ACS Med Chem Lett, 3 (2): 159-64. [PMID:24900446]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 6. Last modified on 29/01/2016. Accessed on 20/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2376.