kallikrein related peptidase 6

Target id: 2376

Nomenclature: kallikrein related peptidase 6

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for kallikrein related peptidase 6 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 244 19q13.3 KLK6 kallikrein related peptidase 6
Mouse - 253 7 B4-B5 Klk6 kallikrein related-peptidase 6
Rat - 251 1q22 Klk6 kallikrein related-peptidase 6
Previous and Unofficial Names
brain serine protease | BSP | kallikrein 29 | kallikrein 6 | Klk29 | Klk7 | MSP | myelencephalon-specific protease | neurosin | protease serine 9 | protease, serine, 18 | Prss18 | Prss9 | kallikrein-related peptidase 6
Database Links
Specialist databases
MEROPS S01.236 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 5 {PMID: 24900446] Hs Inhibition 5.8 pIC50 1
pIC50 5.8 (IC50 1.5x10-6 M) [1]

References

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1. Liang G, Chen X, Aldous S, Pu SF, Mehdi S, Powers E, Giovanni A, Kongsamut S, Xia T, Zhang Y et al.. (2012) Virtual Screening and X-ray Crystallography for Human Kallikrein 6 Inhibitors with an Amidinothiophene P1 Group. ACS Med Chem Lett3 (2): 159-64. [PMID:24900446]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 6. Last modified on 29/01/2016. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2376.