kallikrein related peptidase 7

Target id: 2377

Nomenclature: kallikrein related peptidase 7

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for kallikrein related peptidase 7 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 253 19q13.33 KLK7 kallikrein related peptidase 7
Mouse - 249 7 B2 Klk7 kallikrein related-peptidase 7 (chymotryptic, stratum corneum)
Rat - 261 1q22 Klk7 kallikrein-related peptidase 7
Previous and Unofficial Names
kallikrein-7 | protease, serine, 6 | Prss6 | SCCE | serine protease 6 | thymopsin | kallikrein related-peptidase 7 (chymotryptic
Database Links
Specialist databases
MEROPS S01.300 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 3 [PMID: 23849879] Hs Inhibition 7.4 pIC50 1
pIC50 7.4 (IC50 4x10-8 M) [1]
compound 4d [PMID: 25489658] Hs Inhibition 7.2 pIC50 2
pIC50 7.2 (IC50 6.4x10-8 M) [2]


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1. Tan X, Furio L, Reboud-Ravaux M, Villoutreix BO, Hovnanian A, El Amri C. (2013) 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg. Med. Chem. Lett.23 (16): 4547-51. [PMID:23849879]

2. Tan X, Soualmia F, Furio L, Renard JF, Kempen I, Qin L, Pagano M, Pirotte B, El Amri C, Hovnanian A et al.. (2015) Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J. Med. Chem.58 (2): 598-612. [PMID:25489658]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 7. Last modified on 29/01/2016. Accessed on 22/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2377.