kallikrein B1

Target id: 2379

Nomenclature: kallikrein B1

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for kallikrein B1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 638 4q35 KLKB1 kallikrein B1
Mouse - 638 8 B1-B3 Klkb1 kallikrein B
Rat - 638 16q11 Klkb1 kallikrein B1
Previous and Unofficial Names
antigen, prostate specific | APS | Klk3 | Kal3 | kallikrein 3, plasma | Kalp1 | KALP15 | kininogenin | plasma kallikrein | kallikrein B, plasma (Fletcher factor) 1 | kallikrein B, plasma 1
Database Links
Specialist databases
MEROPS S01.212 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.34

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 11 [PMID: 16413183] Hs Inhibition 9.3 pKi 2
pKi 9.3 (Ki 5x10-10 M) [2]
Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
lanadelumab Hs Binding 10.1 pIC50 1
pIC50 10.1 (IC50 9x10-11 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Prekallikrein deficiency
Synonyms: Fletcher factor deficiency
OMIM: 612423
Orphanet: ORPHA749

References

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1. Sexton DJ, Viswanathan M. (2014) Plasma kallikrein binding proteins. Patent number: US8816055 B2. Assignee: Dyax Corp.. Priority date: 06/01/2011. Publication date: 26/08/2014.

2. Young WB, Rai R, Shrader WD, Burgess-Henry J, Hu H, Elrod KC, Sprengeler PA, Katz BA, Sukbuntherng J, Mordenti J. (2006) Small molecule inhibitors of plasma kallikrein. Bioorg. Med. Chem. Lett.16 (7): 2034-6. [PMID:16413183]

How to cite this page

S1: Chymotrypsin: kallikrein B1. Last modified on 29/08/2017. Accessed on 20/01/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2379.