kallikrein B1

Target id: 2379

Nomenclature: kallikrein B1

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for kallikrein B1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 638 4q35 KLKB1 kallikrein B1
Mouse - 638 8 B1-B3 Klkb1 kallikrein B, plasma 1
Rat - 638 16q11 Klkb1 kallikrein B1
Previous and Unofficial Names
antigen, prostate specific | APS | Kal3 | kallikrein 3, plasma | Kalp1 | KALP15 | kininogenin | Klk3 | plasma kallikrein | kallikrein B, plasma (Fletcher factor) 1 | kallikrein B, plasma 1 | kallikrein B
Database Links
Specialist databases
MEROPS S01.212 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 11 [PMID: 16413183] Hs Inhibition 9.3 pKi 2
pKi 9.3 (Ki 5x10-10 M) [2]
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
lanadelumab Hs Binding 10.1 pIC50 1
pIC50 10.1 (IC50 9x10-11 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Prekallikrein deficiency
Synonyms: Fletcher factor deficiency
OMIM: 612423
Orphanet: ORPHA749


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1. Sexton DJ, Viswanathan M. (2014) Plasma kallikrein binding proteins. Patent number: US8816055 B2. Assignee: Dyax Corp.. Priority date: 06/01/2011. Publication date: 26/08/2014.

2. Young WB, Rai R, Shrader WD, Burgess-Henry J, Hu H, Elrod KC, Sprengeler PA, Katz BA, Sukbuntherng J, Mordenti J. (2006) Small molecule inhibitors of plasma kallikrein. Bioorg. Med. Chem. Lett., 16 (7): 2034-6. [PMID:16413183]

How to cite this page

S1: Chymotrypsin: kallikrein B1. Last modified on 29/08/2017. Accessed on 15/08/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2379.