pepsinogen 5, group I (pepsinogen A) | A1: Pepsin | IUPHAR/BPS Guide to PHARMACOLOGY

pepsinogen 5, group I (pepsinogen A)

Target id: 2390

Nomenclature: pepsinogen 5, group I (pepsinogen A)

Family: A1: Pepsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for pepsinogen 5, group I (pepsinogen A) in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 388 11q13 PGA5 pepsinogen 5, group I (pepsinogen A)
Previous and Unofficial Names
Pepsin A-5
Database Links
Specialist databases
MEROPS A01.071 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.23.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 3 [PMID: 8410973] Hs Inhibition 8.0 pKi 2
pKi 8.0 (Ki 1.1x10-8 M) [2]
Inhibitor Comments
The approved drug sucralfate can inhibit pepsin enzymatic activity [1].

References

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1. Furukawa O, Matsui H, Suzuki N. (1997) Effects of sucralfate and its components on acid- and pepsin-induced damage to rat gastric epithelial cells. Jpn. J. Pharmacol., 75 (1): 21-5. [PMID:9334882]

2. Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM. (1993) Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J. Med. Chem., 36 (18): 2614-20. [PMID:8410973]

How to cite this page

A1: Pepsin: pepsinogen 5, group I (pepsinogen A). Last modified on 23/07/2015. Accessed on 14/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2390.