suppression of tumorigenicity 14

Target id: 2418

Nomenclature: suppression of tumorigenicity 14

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for suppression of tumorigenicity 14 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 855 11q24-q25 ST14 suppression of tumorigenicity 14
Mouse - 855 9 A4 St14 suppression of tumorigenicity 14 (colon carcinoma)
Rat - 855 8q13 St14 suppression of tumorigenicity 14
Previous and Unofficial Names
epithin | HAI | matriptase/MT-SP1 | membrane-type serine protease | MT-SP1 | protease, serine, 14 (epithin) | Prss14 | serine protease 14 | SNC19 | Tmprss14 | suppression of tumorigenicity 14 (colon carcinoma)
Database Links
Specialist databases
MEROPS S01.302 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.109

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
inhibitor 1 [Colombo et al., 2012] Hs Inhibition 11.0 pKi 1
pKi 11.0 (Ki 1.1x10-11 M) [1]
compound 3 [PMID: 23849879] Hs Inhibition 6.2 pIC50 2
pIC50 6.2 (IC50 5.7x10-7 M) [2]
compound 4d [PMID: 25489658] Hs Inhibition 5.8 pIC50 3
pIC50 5.8 (IC50 1.42x10-6 M) [3]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Ichthyosis, congenital, autosomal recessive 11; ARCI11
Synonyms: Ichthyosis-hypotrichosis syndrome [Orphanet: ORPHA91132]
OMIM: 602400
Orphanet: ORPHA91132
Drugs: 

References

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1. Colombo E, Desilets A, Duchene D, Chagnon F, Najmanovich R, Leduc R, Marsault E. (2012) Design and Synthesis of Potent, Selective Inhibitors of Matriptase. ACS Med.Chem.Lett.3: 530-534.

2. Tan X, Furio L, Reboud-Ravaux M, Villoutreix BO, Hovnanian A, El Amri C. (2013) 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg. Med. Chem. Lett.23 (16): 4547-51. [PMID:23849879]

3. Tan X, Soualmia F, Furio L, Renard JF, Kempen I, Qin L, Pagano M, Pirotte B, El Amri C, Hovnanian A et al.. (2015) Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J. Med. Chem.58 (2): 598-612. [PMID:25489658]

How to cite this page

S1: Chymotrypsin: suppression of tumorigenicity 14. Last modified on 29/01/2016. Accessed on 17/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2418.