suppression of tumorigenicity 14

Target id: 2418

Nomenclature: suppression of tumorigenicity 14

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for suppression of tumorigenicity 14 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 855 11q24-q25 ST14 suppression of tumorigenicity 14
Mouse - 855 9 A4 St14 suppression of tumorigenicity 14 (colon carcinoma)
Rat - 855 8q13 St14 suppression of tumorigenicity 14
Previous and Unofficial Names
epithin | HAI | matriptase/MT-SP1 | membrane-type serine protease | MT-SP1 | protease, serine, 14 (epithin) | Prss14 | serine protease 14 | SNC19 | Tmprss14 | suppression of tumorigenicity 14 (colon carcinoma)
Database Links
Specialist databases
MEROPS S01.302 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.109

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
inhibitor 1 [Colombo et al., 2012] Hs Inhibition 11.0 pKi 1
pKi 11.0 (Ki 1.1x10-11 M) [1]
compound 3 [PMID: 23849879] Hs Inhibition 6.2 pIC50 2
pIC50 6.2 (IC50 5.7x10-7 M) [2]
compound 4d [PMID: 25489658] Hs Inhibition 5.8 pIC50 3
pIC50 5.8 (IC50 1.42x10-6 M) [3]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Ichthyosis, congenital, autosomal recessive 11; ARCI11
Synonyms: Ichthyosis-hypotrichosis syndrome [Orphanet: ORPHA91132]
OMIM: 602400
Orphanet: ORPHA91132
Drugs: 

References

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1. Colombo E, Desilets A, Duchene D, Chagnon F, Najmanovich R, Leduc R, Marsault E. (2012) Design and Synthesis of Potent, Selective Inhibitors of Matriptase. ACS Med.Chem.Lett., 3: 530-534.

2. Tan X, Furio L, Reboud-Ravaux M, Villoutreix BO, Hovnanian A, El Amri C. (2013) 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg. Med. Chem. Lett., 23 (16): 4547-51. [PMID:23849879]

3. Tan X, Soualmia F, Furio L, Renard JF, Kempen I, Qin L, Pagano M, Pirotte B, El Amri C, Hovnanian A et al.. (2015) Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J. Med. Chem., 58 (2): 598-612. [PMID:25489658]

How to cite this page

S1: Chymotrypsin: suppression of tumorigenicity 14. Last modified on 29/01/2016. Accessed on 21/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2418.